19 Oktober 2021 mulai pukul 23.45 WIB
1. Besiktas vs Sporting Lisbon
2. Club Brugge vs Manchester City
20 Oktober 2021 mulai pukul 02.00 WIB
1. PSG vs RB Leipzig
2. Shakhtar Donetsk vs Real Madrid
3. Atletico Madrid vs Liverpool
4. Inter Milan vs Sheriff
5. Porto vs AC Milan
6. Ajax vs Dortmund